Pten cKO osteoprogenitor cells increases bone turnover and influences bone remodeling. Serum markers for bone turnover were quantified using ELISA. (A) Serum P1NP as a marker for bone formation. P1NP was elevated (P = .0052, n = 7 Cre negative (Cre-), n = 9 Pten cKO). (B) C-terminal telopeptide of type 1 collagen (CTX) as a marker for bone resorption was increased (P = .0091, n = 7 Cre-, n = 9 Pten cKO). (C) Number of osteoblasts/bone perimeter (N.Ob/B.Pm) was increased (P = .0095, n = 4 Cre-, n = 6 Pten cKO) in bones from Pten cKO mice compared with controls. (D) Number of osteoclasts/bone perimeter (N.Oc/B.Pm) was not significantly changed (n = 4 Cre-, n = 6 Pten cKO). (E) Trabecular mineralizing surface per bone surface (MS/BS) was higher in Pten cKO femora (P = .003, n = 8 per group) while (F) there was a trend toward higher BFR/BS (, P = .1893, n = 8 Cre-, n = 7 Pten cKO). Data are presented as median with interquartile range.