Tumor cell types differ in pathway enrichment. a. Enrichment in gene sets from adult HGG shows intertumoral heterogeneity based on bulk RNA-seq data (FDR < 1.6E−4 for all gene sets); b. Tumor cell types and microglia vary in enrichment of adult HGG gene sets; c. Pathway analysis in tumor cell types; d. Histone methylation mark gene sets predicting stemness/differentiation (greater enrichment in these gene sets suggests greater cell differentiation); e. Heatmap summarizing pathway enrichment shows differences in oncogenic processes and targetable signaling pathways among principal tumor cell types.