Diagnostic performance of AI-imputed tau-PET. (A–D) Meta-ROI (region of interest) standardized uptake value ratios (SUVRs) from the actual tau, FDG-, T1-weighted (T1W)-, and Pittsburgh compound B (PiB)-based artificial intelligence (AI)-imputed tau-PET were plotted for each diagnostic group. Red, blue and grey coloured dots show amyloid positive, negative and unknown, respectively. (E–G) Receiver operating characteristic (ROC) analysis was performed for classifying the diagnostic groups using seven predictors. Open circles indicate different folds. Statistical significance was assessed with two-way ANOVA and Holm-Sidak post hoc comparison. Aβ = amyloid-β; CUA = cognitively unimpaired with normal amyloid; CUA+ = cognitively unimpaired with abnormal amyloid level; MCI = mild cognitively impaired; AD = Alzheimer’s disease; LPA = logopenic progressive aphasia; PCA = posterior cortical atrophy; PSP = progressive supranuclear palsy; FTD = frontotemporal dementia; SD = semantic dementia; nfvPAA = non-fluent variant of progressive associative agnosia; RBD = REM sleep behaviour disorder; DLB = dementia with Lewy bodies; spec = spectrum. **P < 0.01, ***P < 0.0001.
