Region-wise associations between regional tau-PET SUVR and cognitive performance and decline in participants with MCI and Alzheimer’s disease. Association between tau-PET SUVR and cognitive performance (A) and cognitive decline (B) in participants with MCI and with Alzheimer’s disease across four cognitive domains (memory, executive functioning, language and visuospatial). Cognitive decline was computed for each participant with more than two cognitive time points using linear mixed-effect models with random slopes and intercepts. The standardized β coefficients of the associations between tau-PET SUVR in a specific region and each cognition measure are displayed if it survives adjustment for age, sex and education and a multiple comparison FDR correction (P_corrected < 0.05).