Association between tau-PET measures, and memory performance and decline. (A) Memory performance closest in time to the tau-PET scan and (B) memory decline computed across the study period were associated with both temporal meta-ROI SUVR and spatial extent index in Aβ-positive participants using linear regressions. Cognitive decline was computed for each participant with more than two cognitive time points using linear mixed-effect models with random slopes and intercepts. In each panel, columns represent a diagnostic group (leftmost: whole sample, second from the left: cognitively unimpaired, second from the right: mild cognitive impairment, right-most: Alzheimer’s disease). Simple and standardized β coefficients, adjusted R2 and Akaike information criterion, controlled for age sex and education, are shown on the graphs. P-value of models are indicated next to the simple beta coefficients. (°: P < 0.1, *: P < 0.05, **: P < 0.01, ***: P < 0.001) Results remained significant after a multiple comparison FDR correction.
