Scatter plots showing change over time of pons diameter and BARS scores in MSA-C. Scatter plots of rate of change over time of (A) AP Pons diameter and (B) BARS scores in the Exploratory cohort. There were 88 patients with MSA-C in the Exploratory cohort. Of these, 31 were in the early stage of the disease (0–3 years), and two patients were in the late stage of the disease (10–13 years). AP, anteroposterior; BARS, Brief Ataxia Rating Scale; MSA-C, multiple system atrophy of the cerebellar type.