Subgroup analysis for the primary efficacy endpoint. The forest plot derived from Cox regression analysis shows HR estimates (squares) with 95% CI (horizontal bars) for the treatment effects (HG vs. SG) in prespecified subgroups. The widths of the CI and P-values are not adjusted for multiple comparisons. No apparent heterogeneity of effects across subgroups using treatment-by-covariate terms was observed. AF, atrial fibrillation; BMI, body mass index; CAD, coronary artery disease; CI, confidence interval; Cryo-Ar, argon-based cryoablation; Cryo-N, nitrogen-based cryoablation; HG, hybrid group; LA, left atrium; LVEF, left ventricular ejection fraction; NYHA, New York Heart Association classification of heart failure; SG, surgery group.