Time series for each case, displaying cycle threshold (Ct) values of SARS-CoV-2 on reverse-transcription quantitative polymerase chain reaction over time for 7 cases. Cases without follow-up testing data (n = 2) and cases where upper respiratory tract sampling was consistently negative (n = 2) are not shown. Sampling date is presented in relation to the start date of the final course of nirmatrelvir/ritonavir. Samples are shown up to 90 days prior to this final course. Samples reported as not detected are set to Ct = 46 for the purpose of graphical representation. Multiple platforms were used for testing, and no correction or normalization between platforms was conducted.