Schematic diagram of SCMV antagonises host resistance by employing 6K2 to impair ScPIP2;4 transport of H₂O₂ to facilitate virus infection. SCMV infection induces the expression of RBOHD and ScPIP2;4. Apoplastic H₂O₂ is generated by the RBOHD coupled with SOD. The homo- or hetero-tetramerization of ScPIP2;4 occurred in ER. Then the ScPIP2;4 tetramer translocates to PM to transport apoplastic H₂O₂ into the cytoplasm to inhibit the replication of SCMV genome. To antagonise the host resistance mediated by H₂O₂, SCMV employs 6K2 to interact with ScPIP2;4 via the TM5, thereby interfering with the oligomerization and or the PM localization of ScPIP2;4, subsequently impairing the transport of apoplastic H₂O₂ into cytoplasm. Black arrows indicate promoting effects. Blue arrows indicate transcription or translation. Red arrows indicate translocation. Curved arrows indicate the direction of electrons transfer. Blunt arrows indicate inhibiting effects. Abbreviations: ER, endoplasmic reticulum; PM, plasma membrane; RBOH, RESPIRATORY BURST OXIDASE HOMOLOG; SCMV, Sugarcane mosaic virus; SOD, superoxide dismutase.