Current and suggested future workflow. (A) Current research within driver gene prediction, driver mutation prediction and structural assessment of mutations is characterized by tools within these fields working in silos. Such an approach risks overlooking potential synergies. (B) To overcome some of the challenges by this approach, a suggested protocol for the future development of these fields is illustrated. This protocol includes the collective study of the driver gene prediction, driver mutation and structural assessment of mutation fields, with each field serving as the input to the next, creating a funnel approach. Such a novel workflow would include initial driver gene prediction, selection of driver genes, driver mutation prediction in the predicted driver genes, and, finally, choice of mutations to be studied structurally to assess the impact of these mutations on protein function and stability. This will result in a set of damaged proteins for further exploration.