Multi-variable Cox regression analysis of 2552 coronary flow reserve maps after prior revascularization with 12 years follow-up for, Observed coronary flow reserve associated survival probability for severely reduced (blue lines) and non-severely reduced coronary flow reserve (black lines) with (dashed lines) and without (solid lines) revascularization. While survival probability is significantly improved for severely reduced coronary flow reserve after another revascularization, substantially reduced survival probability persists (dashed blue line) that is comparable to the post-revascularization survival probability with no severely reduced coronary flow reserve (solid black lines) after the first revascularization. The numbers with no severely reduced coronary flow reserve after the first revascularization having another revascularization are too small for statistical analysis. CI, confidence intervals