Colocalization and evolution of retroCNVs in humans. a) Density plots showing the distribution of colocalization frequency between chromatin pairs under different null models for singleton retroCNVs (left panel) and high-frequency retroCNVs (right panel). The arrows point to the colocalization frequency between true retroCNVs and their parental genes. Simulations and true frequencies are based on Hi-C data in GM12878. P-values are indicated for simulation 5. b) The presence frequency spectra for retroCNVs that are colocalized in 0, 1, and ≥2 cell lines.