Antero-posterior kinetics of the aorto-mitral annulus in G+LVH− and G+LVH+ compared with controls. Two-dimensional antero-posterior displacement-vs.-time plots in G+LVH−/G+LVH+ vs. matched controls normalized for R–R intervals and baseline positions. Motion tracking software measured the ROI position in each cine frame during the cardiac cycle. Data symbols indicate mean cohort values, and unidirectional whiskers indicate standard errors. Significant P values are highlighted in bold. Red ribbons highlight statistically significant SAM of the AMVL in overt and subclinical HCM. HCM, hypertrophic cardiomyopathy; SAM, systolic anterior motion. Abbreviations as in Figures 1 and 2.