Complex relationships between the microbiome, social determinants of health, and health inequities in CDI. This figure demonstrates how social and structural determinants of health, as well as health and lifestyle factors, shape the gut microbiome and its influence on CDI. These relationships demonstrate that different patient populations may experience health disparities, providing valuable insights for addressing CDI outcomes and promoting health equity. Abbreviation: CDI, Clostridioides difficile infection. (Created with BioRender.com)