Ileal mucosa-associated bacterial microbiome in 95 mucosal pinch biopsy specimens (sampled from 5 and 15 cm proximal from the ileocecal valve or anastomosis) from 51 Crohn’s disease patients according to endoscopic inflammation (Rutgeerts score ≥1) and histologic inflammation (GHAS and Robarts score ≥1) at biopsy sample location. A, Alpha diversity, illustrated by Shannon entropy index, according to endoscopic inflammation compared with Wilcoxon test. B, Alpha diversity, illustrated by Shannon entropy index, according to histologic inflammation compared with Wilcoxon test. C, Beta diversity illustrated by Bray-Curtis dissimilarity index on nonmetric multidimensional scaling plot in 95 mucosal pinch biopsies from 51 CD patients and 80 mucosal pinch biopsies from 40 healthy controls; each sample colored according to endoscopic inflammation (yes or no) or HC. D, Beta diversity illustrated by Bray-Curtis dissimilarity index on nonmetric multidimensional scaling plot in 95 mucosal pinch biopsies from 51 CD patients; each sample colored according to histologic inflammation (yes or no).