Overview of GLP1R variants found in the Danish and UK Biobank cohorts. The green circle shows the total number of variants in exome regions with 50 bp overhangs, the blue circle shows the nonsynonymous variants, the yellow circle displays the number of predicted loss-of-function variants, and the red circle shows in vitro determined loss-of-signaling variants. A, Danish cohorts (solid line); B, UK Biobank (dashed line); C, Comparison of the variants found in the Danish cohorts and the UK biobank cohort. The numbers outside the circles represent the total number of variants within a given group.