A, Mean Radiographic Global Impression of Change (RGI-C) rickets and lower-limb deformity score with burosumab vs conventional therapy stratified by prebaseline doses of oral phosphate using published dose thresholds. B, Mean RGI-C rickets and lower-limb deformity score with burosumab vs conventional therapy stratified by prebaseline doses of active vitamin D using published dose thresholds. C, Mean (SE) RGI-C rickets and lower-limb deformity scores with burosumab vs on-study doses of phosphate using published dose thresholds. D, Mean (SE) RGI-C rickets and lower-limb deformity scores with burosumab vs on-study doses of active vitamin D using published dose thresholds. Number above error bar is the mean; error bar denotes SE; number within column is number of patients contributing to the result shown.