Change in glycemic control and body composition with 20 weeks of semaglutide treatment (green, n = 12), followed by 12 weeks of exercise combined with semaglutide (blue, n = 16), and corresponding change with exercise alone (red, n = 15), in patients with type 2 diabetes. In all panels, mean values are presented with standard errors (I bars). P values in A and B indicate the change with semaglutide and the main effect with the training intervention. Within group changes were analyzed by repeated measures 2-way ANOVA for Semaglutide + Training, and Training. A 2 sided paired Student’s t-test was used for evaluation of semaglutide alone. Fasting plasma glucose was lower with semaglutide alone and in combination with training than training alone before and after the training intervention (P = .022, repeated measures, 2-way ANOVA). Asterisks denotes change within the group: *P < .05, **P < .01, and ***P < .001.