Usefulness of systematic LP in patients without HIV who have cryptococcosis but no clinical neurological abnormalities at the time of presentation. *The presence of suggestive clinical neurological abnormalities was defined as the presence of at least 1 of the following signs/symptoms: headache, meningeal symptoms, altered mental status, confusion, lethargy, seizures, syncope/falls, focal neurological signs. **A high serum CrAg titer was defined as ≥1:320 for study sites that used the Immuno-Mycologics Inc CrAg lateral flow assay and ≥1:256 for study sites that used latex agglutination. Abbreviations: CrAg: Cryptococcus antigen; HIV, human immunodeficiency virus; LP, lumbar puncture; NB, nota bene.