Figure 1.
(A) Paired longtail of genomic alterations found in 205 patients of East Asian (EAS) and 7447 patients of European (EUR) genomic ancestry with UCB. Mutations in TERT promoter (73.60% vs. 54.15%; P = 6.34E−08) and PIK3CA (22.09% vs. 12.68%; P = 6.34E−08) are enriched in the EUR group. The most frequent 25 genes ordered by combined frequency in both cohorts are shown. (B) Tile plot of pathogenic genomic alterations identified in 205 patients with UCB of East Asian genomic ancestry. MSI-high was detected in 1.5% of patients were MSI-high and 7.3% were TMB-high (>20 mut/Mbp). (C) Volcano plot showing enrichment (P < .05) for pathogenic gene alterations between EAS and non-EAS groups. EMSY, NSD3, FGFR1, and PAX5 are significantly enriched in the EAS group while TERT promoter and PIK3CA are enriched in the non-EAS group.

(A) Paired longtail of genomic alterations found in 205 patients of East Asian (EAS) and 7447 patients of European (EUR) genomic ancestry with UCB. Mutations in TERT promoter (73.60% vs. 54.15%; P = 6.34E−08) and PIK3CA (22.09% vs. 12.68%; P = 6.34E−08) are enriched in the EUR group. The most frequent 25 genes ordered by combined frequency in both cohorts are shown. (B) Tile plot of pathogenic genomic alterations identified in 205 patients with UCB of East Asian genomic ancestry. MSI-high was detected in 1.5% of patients were MSI-high and 7.3% were TMB-high (>20 mut/Mbp). (C) Volcano plot showing enrichment (P < .05) for pathogenic gene alterations between EAS and non-EAS groups. EMSY, NSD3, FGFR1, and PAX5 are significantly enriched in the EAS group while TERT promoter and PIK3CA are enriched in the non-EAS group.

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