(A) Residual cancer burden (all patients); (B) Residual cancer burden among patients who had surgery. Abbreviations: CI, confidence interval; ICR, independent central review; ITT, intent-to-treat; PD, progressive disease; RCB, residual cancer burden. ^aThe denominator is N, the number of patients in the evaluable/ITT analysis set as per ICR. ^bThe simultaneous exact CI was calculated using Goodman’s method. ^cNone of the patients who had pathology submitted are classified as RCB III. ^d10 patients in the evaluable and ITT population had PD and are counted in the “Missing” category. Two patients did not have surgery for other reasons (early discontinuation and consent withdrawal; ITT population), and 1 patient was unable to be assessed because of missing a required axillary specimen. ^eOne patient was unable to be assessed because of missing a required axillary specimen.