Left ventricular ejection fraction (LVEF) and global longitudinal strain (GLS) in all patients. The graphs show LVEF (a) and GLS (b, scale reversed for ease of interpretation) in all patients (n = 51) in the study. Bars represent percent of patients on trastuzumab at each time point. Table accompanying each graph shows the number of patients who demonstrated normalized LVEF (≥54%) or normalized GLS (≤-17% or to baseline level) at each time point. P-values represent the comparison of LVEF or GLS with baseline values at selected time points.