Suggested strategy for potential reversal of non-vitamin K oral anticoagulants effect.

aPTT, activated partial thromboplastin time; dTT, diluted thrombin time; FXa, factor Xa; N, no; NOAC, non-vitamin K antagonist oral anticoagulant; PT, prothrombin time; UFH, unfractionated heparin. Y, yes; ^aConditions that are potentially life-threatening or that may threaten the survival of limb or organ. ^bConditions that can be managed and procedure delayed for several days. ^c>24 h in case of significantly reduced renal function (i.e. eGFR <50 mL/min). ^dIf specific reversal agent is unavailable, consider non-specific haemostatic agents (prothrombin complex concentrate [PCC] or activated PCC [aPCCs]). Idarucizumab has only been tested in patients undergoing urgent surgery. Andexanet has not been tested in patients requiring urgent surgery. Andexanet binds all FXa inhibitors (including UFH) non-specifically. ^eUpon re-check.