P2Y₁₂ inhibitor interruption after percutaneous coronary intervention before elective non-cardiac surgery.

LoE, level of evidence; MI, myocardial infarction; N, no; PCI, percutaneous coronary intervention. Y, yes; ^aAvailability of 24 h cath-lab service is suggested in case of major surgery within 6 months in non-ACS/non-high-risk patients and within 12 months in ACS/high-risk patients. ^bHigh risk of peri-operative stent thrombosis defined by at least one of the following: history of recurrent MI, history of stent thrombosis under antiplatelet therapy, reduced left ventricular ejection fraction (<40%), poorly controlled diabetes, severely impaired renal function/haemodialysis, recent complex PCI (i.e. severely calcified lesion, left main PCI, chronic total occlusion, bifurcational/crush technique, bypass graft PCI), stent malapposition/residual dissection. ^cClass III LoE C. ^dClass IIa LoE B ^{250,265, 266,267}. ^eClass I LoE A ^268,146. ^fClass III LoE B ²⁶⁹. ^gClass IIb LoE B ^{270, 271}. ^hClass IIa LoE B ^{272,273,274, 275, 276,277,278}. ⁱClass I LoE A ^{279, 280, 281, 98}.