A) The percentage of correct selection (PCS) of the optimal dose, (B) generalized power (%), (C) the average sample size, and (D) the toxicity rate of designs A-D, with the null and target ORRs of 0.2 and 0.4, respectively, and the target hazard ratio of 0.64. In panels (C) and (D), NI represents noninferential or operational counterparts of designs A-D, which disregard phase II data, and HD represents the counterparts with only the highest dose evaluated in phase II. ORR = objective response rate; PCS = percentage of correction selection.