Association of baseline tau-PET burden with rate of cognitive decline, stratified per determinant of interest. For visualization purposes, annual change in MMSE (points/year) was calculated for each participant through an individual level regression of all available MMSE observation on time (in years). Continuous determinants were divided in tertiles. ICV = intracranial volume; MMSE = Mini-Mental State Examination; ROI = region of interest; SUVR = standardized uptake value ratio.