An atlas of microbial phenylalanine and tyrosine pathways associated with MACE. Metabolic pathways for aromatic acid fermentation together with their association with MACE (red chemical structures for compounds positively associated with MACE while green structures for compounds negatively associated with MACE after adjusting for traditional risk factors and hsCRP) and effect of gut microbe depletion on their circulation levels both in humans (blue (left) arrow) and mice (red (right) arrow); (−) no effect. Abx = antibiotics.