Mean change in weight (kg) from randomization to 48, 72, and 96 h in dapagliflozin vs. metolazone groups. Model-predicted mean change in weight from baseline with 95% confidence intervals at each time point. The treatment effect estimate displayed in the text represents the between-group difference (dapagliflozin vs. metolazone) in the common effect estimate between 48 and 96 h.