Trends of comorbidities and Charlson index in patients with device-related infection (DRI) from 2011 to 2018. Trends for coronary artery disease (P = 0.94) and end-stage renal disease (P = 0.88) were statistically insignificant while all other comorbidities showed significant interval increase (P < 0.001 for all others). CAD, coronary artery disease; Charlson, Charlson comorbidity index; CHF, congestive heart failure; DM, diabetes mellitus; ESRD, end-stage renal disease.