GL261-bearing mice develop seizures at a late stage of the disease after hampering GABA-A receptor signaling. (A) On the left is representative image of a mouse implanted with chronic electrodes to record local field potentials (LFPs). On the right is experimental protocol. (B) Representative LFP recordings in controls (left) and glioma-bearing (right) mice after DMCM administration. Traces at the bottom show activity on an enlarged scale to better appreciate seizure events. (C, D) Frequency of seizure in control (C) and glioma-bearing mice (D) before and after saline or DMCM administration. The mean ± sem is also shown (*, P < .05).