Neutrophil activation induced by plasma from patients with PMR. Neutrophils from a healthy individual were incubated with plasma from HCs (n = 20) and patients with PMR (n = 45) and analysed for the expression of the neutrophil cell surface degranulation markers CD66b (A) and CD11b (B) by flow cytometry. Results are presented as the mean fluorescence intensity (MFI). Statistical analyses were done using the Mann–Whitney U-test; ***P < 0.001. Each circle represents an individual sample, with the bar representing the median of the group. HC: healthy control