DDAH1 Tg mice reversed the lipodystrophic-like phenotype in renal insufficiency. (A) The results of the insulin tolerance test in DDAH1 Tg mice. The IR in WT littermates after Nx was ameliorated in DDAH1 Tg mice. (B) The ADMA content in the adipose tissue of DDAH1 Tg mice. The accumulation of ADMA in WT littermates after Nx was ameliorated in DDAH1 Tg mice. (C) The weight of white adipose tissue (WAT) in DDAH1 Tg mice. The adipose tissue atrophy in WT littermates after Nx was ameliorated in DDAH1 Tg mice. (D) The size of adipocytes in DDAH1 Tg mice. The decrease in adipocyte diameters in WT littermates after Nx was reversed in DDAH1 Tg mice. (E) The lipid accumulation in the liver in DDAH1 Tg mice. The ectopic lipid deposition in WT littermates after Nx was ameliorated in DDAH1 Tg mice. *P < 0.05 versus WT littermate without Nx, ^##P < 0.01 versus WT littermate with Nx, n = 6. Data are presented as mean ± SEM.