Daytime activity only. Percent of daytime spent highly active (>2,000 counts) are shown for each experimental group at different time-points pre/post injury/anesthesia. Mixed-effects analysis shows an overall significant effect of time across all groups (F(2.115, 57.81) = 10.02, P = 0.0001); pairwise comparisons used Tukey’s multiple comparisons test. Significant decreases occurred in the Injury + Stress group at 4 weeks and 4 months post injury compared to Baseline. Note: Only Cohort 3 continued to 4MPI and 6MPI; therefore, there is a lower n at these time-points.