Six months post injury actigraphy graphs and corresponding LOESS plots. Two examples from Cohort 3 are shown per experimental group. The top row (actigraphy: A, B; LOESS: A’, B’) are example plots from the Sham group, the middle row (C, D, C’, D’) shows plots from the Injury group, the bottom row (E, F, E’, F’) provides plots from the Injury + Stress group. The actigraphy plots (A, B, C, D, E, F) show the activity counts per minute in black from midnight to midnight; the period of time with the lights on is highlighted in dark gray (from 7 A.M. to 7 P.M.). The lighter gray shaded area highlights the 2,000 count level of activity. The LOESS plots indicate the 95% interval with dotted lines; a solid black line highlights the 2,000 count level. Both the actigraphy and LOESS plots denote strong clustering in the Sham animals, with less clustered activity in the Injury plots, and a continued reduction in the Injury + Stress plots. Note: Only Cohort 3 is shown because Cohorts 1 and 2 did not survive to this time-point.