PPI cross-disease correlation and cross-disease module mining in ND. (A) The cross-disease PPI data statistics show the number of shared associations and interactions between NDs. Each arc represents a kind of ND, and the longer the arc, the more the number of PPIs related to the disease. Twelve kinds of NDs were selected to calculate the overlap, and there are shared interactions among diseases involving neurodegenerative symptoms. DLB: Lewy body dementia; SPAX: Spastic ataxia; ICRD: Infantile cerebellar-retinal degeneration; PIDB: Pick’s disease (frontotemporal dementia). (B) A protein interaction module whose function is significantly enriched in neurophysiologically related items such as cell death, cellular homeostasis and nervous system development. The proteins in the module are more closely related to other proteins in the network through PPI. AD: Alzheimer diseases; PD: Parkinson’s disease; Cross: cross multiple diseases; CAR: autosomal recessive cerebellar ataxia; HD: Huntington’s disease; ICRD: infantile cerebellar–retinal degeneration; ADCA: autosomal dominant cerebellar ataxia. (C) DNAJA3 protein isoform 2 and its first adjacent node interacting proteins, the dotted line represents that these corresponding interactions all involve the isoform DNAJA3-2.