Estimated CD4 cell-count trajectory (based on a linear mixed model including subject-specific knots at time from antiretroviral therapy (ART) initiation to disengagement from care |$\left({D}_i\right)$| and ART reinitiation |$\left({R}_i\right)$|⁠, fitted to data from the IeDEA Collaboration) among individuals who disengaged from and subsequently reengaged in care, East Africa, 2001–2011. It is estimated assuming that |${D}_i=3$| months or |${D}_i=12$| months, with the time gap from disengagement to ART reinitiation being |$\left({R}_i-{D}_i\right)=3$| months or |$\left({R}_i-{D}_i\right)=6$| months. For comparison, the estimated CD4 evolution assuming no disengagement (solid line) is also presented. AIDS, acquired immunodeficiency syndrome; IeDEA, East Africa International Epidemiology Databases to Evaluate AIDS.