(A) B-Mode ultrasound end-systolic images of the left ventricular of Kv1.5−/− mice under control conditions, following transaortic constriction [2 weeks (2W)], and debanding (removal of the transaortic constriction) for 2 weeks. (B) Fractional shortening (%FS) of the left ventricular apex and base of wild-type and Kv1.5−/− mice under baseline conditions, 2 weeks after transaortic constriction (2W transaortic constriction), 2 weeks after debanding (2W transaortic constriction + 2W deband, 4 weeks after debanding (2W transaortic constriction + 4W deband). Sample sizes: wild-type-control, base n = 18; wild-type -control, apex n = 11; wild-type-transaortic constriction, n = 16; wild-type-2W transaortic constriction + 2W deband, n = 12; 2W transaortic constriction + 4W deband base, n = 12; 2W transaortic constriction + 4W deband apex, n = 11; Kv1.5−/−-control base, n = 6; Kv1.5−/−-control apex, n = 11; Kv1.5−/− −2W transaortic constriction + 2W deband, n = 12; Kv1.5−/− −2W transaortic constriction + 4W deband, n = 12. If base and apex are not mentioned, the sample sizes are equal for the two regions in the group. The data sets were analyzed by a one-way ANOVA followed by Šídák’s multiple comparison test. ANOVA, analysis of variance; CI, confidence interval.
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