Reactivity of antibodies to topo-I and AT₁R in SSc-patients before and after aSCT. Sera from 43 SSc-patients were tested for anti-topo-I- and anti-AT₁R antibodies by ELISA (a) and immunoglobulins from 25 SSc-sera for functional anti-AT₁R antibodies by a luminometric assay (b) at different time points. Time point 0=before aSCT: n =43, 1=1–4 months after aSCT: n =39; 2=5–9 months after aSCT: n=34; 3=10–17 months after aSCT: n=27; 4=18–24 months after aSCT: n=24; 5=25–36 months after aSCT: n=20; 6≥$$36 months after aSCT: n=11. Anti-topo-I antibodies refer to the left, anti-AT₁R antibodies to the right y-axis (a). Functional reactivity (b) is given as a factor related to that of healthy controls. The normal range is indicated in grey. Individual values and the median as well as significance values are given. ns=not significant