Expression of yes-associated protein 1 (YAP1), miR-21-5p, and progesterone receptor (PGR) in the clinical specimens of endometriosis. Expression levels of miR-21-5p (A) and PGR and PGR-B (B) were quantified in the paired endometrial and endometriotic tissues by qRT-PCR (n = 9 pairs of eutopic (Eu) and ectopic (Ec) samples). Asterisks (*) indicate P < 0.05. Results were presented as mean ± SEM. Representative images (C) and quantified results (D) of PGR in paired Eu endometrial and Ec endometriotic tissues (n = 42). St: stromal cells, Epi: glandular epithelial cells. Asterisk indicates p < 0.05. (E) Representative immunohistochemistry images show the inverse correlation of PGR (upper panel) and YAP1 (lower panel) in Ec endometriotic tissues. (F) Expression levels of YAP1, miR-21-5p, and PGR from the same paired endometriotic specimens were quantified by RT-qPCR. Data were presented as fold over Eu (n = 7). (G) Heat map showed the correlation analyses of YAP1, miR-21-5p, PGR, and its downstream targets in the public dataset (GSE51981) containing a large cohort of endometriotic tissues. Statistical test was performed by using Pearson's correlation test.