Recommendations on reversal agents in patients with intracranial hemorrhage. Treatment algorithm adapted from the 2022 American Heart Association and American Stroke Association guidelines for the management of spontaneous intracerebral hemorrhage.⁸⁰ Green color indicates class of recommendation 1a, yellow indicates class 2a, orange indicates class 2b, red indicates class 3. INR, international normalized ratio; 4-F, four-factor; PCC, prothrombin complex concentrates; aPCC, activated prothrombin complex concentrates.