PHACTR1 coronary artery disease risk allele (GG) did not impact on in vivo vascular function. (A) In vivo dilator response to flow (FMD) was not different across the genotypes (GG; P > 0.05, one-way ANOVA, GG = 102, GA = 189, and AA = 138 subjects per genotype). (B) No difference between genotypes was observed in endothelial cell-independent dilation (EID, GG = 73, GA = 142, and AA = 101 subjects per genotype) in response to GTN in vivo. Population was subdivided into non-hypertensive (no HTN). (C) (G = 66, GA = 147, and AA = 105 subjects per genotype) and (D) (G = 61, GA = 134, AA = 94 subjects per genotype) and hypertensive (E) (G = 76, GA = 139, and AA = 97 subjects per genotype) and (F) (G = 33, GA = 83, and AA = 54 subjects per genotype) no difference was observed in either FMD or EID across the genotypes in either population.