Two-year combined device-related chronic complication and select reinterventions. Notes: hazards ratios of 2-year combined device-related chronic complications (device breakdown, dislodgment, other mechanical complications, infection, device-related pain, device-related stenosis, and pocket complications) and select reinterventions (system revision, lead revision or replacement, system replacement, system removal) rates between leadless-VVI patients and transvenous-VVI patients for each high-risk subgroup, estimated with Fine–Gray competing risk models. Spikes represent Bonferroni-adjusted confidence intervals (number of tests = 27). aDCSI, adapted Diabetes Complication Severity Index; COPD, chronic obstructive pulmonary disease; CKD, chronic kidney disease; ESRD, end-stage renal disease. ESRD and CKD Stages 4 or 5 are not mutually exclusive.