Validation of drug resistance driver genes. (A) Compare the mutation frequency between driver genes and non-driver genes in different conditions (^*: P < 0.05, ^**: P < 0.01, ^***: P < 0.001, ns: P > 0.05). (B) Enrichment of all driver genes in the four functional gene sets. CGC: CGC genes; DTG: drug targets; KRG: known resistance genes; EMT: EMT genes. (C) Enrichment of driver genes of each condition in the four functional gene sets. The size of point indicates the statistical significance. The blank represents the intersection of these two gene sets is not significant. (D) Functional enrichment of driver genes in all conditions. Here only displays the top 10. (E) Functional enrichment of driver genes in each condition. The color represents the significance of functional analysis. The functions listed on the left are shared functions. The LGG_Temozolomide specific functions are listed on the right.