Largest longitudinal changes in the CDR®+NACC FTLD sum of boxes scores (first row) and CBI-R total scores (second row) in the presymptomatic mutation carriers for those with ‘normal’ and ‘abnormal’ w-scores for GM and WM regions.Y-axis represents estimated marginalized means. Asterisks indicate a significant difference in progression between visits within the two groups at Wilcoxon Signed Rank exact test (P ≤ 0.05). Bars indicate the 95% confidence intervals of the mean. Analyses were performed on: C9orf72 n = 56; MAPT n = 32; GRN n = 69. Abbreviations. DLPFC, dorsolateral prefrontal; VMPFC, ventromedial prefrontal; MED PARIETAL, medial parietal, FA, fractional anisotropy; MD, mean diffusivity; UF, uncinate fasciculus; SS, sagittal stratum; gCC, genu of the corpus callosum; sCR, superior corona radiata; aCR, anterior corona radiata.