CircRNAs acts as a sponge for miRNAs and the ceRNA network. The luciferase reporter assays in RAW264.7 cells co-transfected with wild-type or mutant circ-Cd84/ circ-Wdr91/circ-Tns3 luciferase vector and control (A1-5) or miR-378a-5p/miR-378c/let-7d-5p mimics (B1-3). The wild-type and mutant sites of the circRNAs and mRNAs with miRNAs are shown in red color (C). The interaction of 3 ceRNAs (circ-Tns3/let-7d-5p/Ctsl, circ-Wdr91/miR-378a-5p/Msr1, and circ-Cd84/miR-30c/TLR2) (D). The ceRNA network is shown in graph (E). Three miRNAs (red color) are the center of the regulation, purple and green colors represent circRNAs and mRNA, respectively