Impact of sustained virologic response (SVR) on depressive symptoms in the HIV-HCV coinfected population (A). Results of the primary analysis model with outcome misclassification correction. The graph shows that pre-treatment the probability trend for presence of depressive symptoms was stable over time. There was no evidence of immediate change at SVR; however, the probability trends post-SVR indicate a gradual decline in depressive symptoms over time (B). Results of the sensitivity analysis model to assess lead time bias with outcome misclassification correction. In this model, we lagged SVR by 1 year to assess possibility of lead time bias. The graph shows a stable pre-treatment trend like the primary analysis. The increase in the immediate level of depressive symptoms prevalence 1-year pre-SVR, provides evidence for no lead time bias in this analysis, meaning depressive symptoms did not seem to improve in anticipation of the cure. Abbreviations: HCV, hepatitis C virus; HIV, human immunodeficiency virus.