Suppression of SWO-induced homeostatic synaptic potentiation by DEAB decreases epileptic SWD incidence in het Gabrg2^+/Q390X KI mice. Panels A/B show representative pre-DEAB and post-DEAB EEG/EMG traces (30 s) in one wt littermate. Panels C/D show representative pre-DEAB and post-DEAB EEG/EMG traces (30 s) in one het KI mouse. SWDs are indicated as arrowheads, and one SWD is expanded with a smaller temporal scale in panel C. All scale bars are labelled as indicated. Panels E/F show summary SWD incidence and duration data for wt littermates (n = 7, male 5, female 2) and het KI mice (n = 9, male 2, female 7). Panels G/H show summary pre-DEAB and post-DEAB SWD incidence and duration data from het KI mice during NREM/REM/wake period. * indicates paired t-test significance with P < 0.05 between pre-DEAB and post-DEAB in panels E–H (also see result section). One-way ANOVA was tested for pre-DEAB (not shown) or post-DEAB (shown) NREM, REM and wake period for panels G and H, with significance &&& P < 0.00001.