Genotype-specific cumulative breast cancer risks. For female breast cancer, the genotype-specific cumulative cancer risk by variant coding effect and domain is presented for the prevalent cohort excluding index patients who had cancer before genetic testing (ca-index patients). Per age category, the number of females at risk and cumulative number of breast cancer events are presented. At the end, the cumulative number of breast cancer events (n) and the total number of patients included in each genotypic category (N) are presented. C2 = C2 domain; missense = missense variants; other = other domain location than C2 or PD alone; PD = phosphatase domain; truncating = truncating variants.