Aggregated representation of segmented T2-hyperintense areas after spatial normalization to a standard atlas (MNI152). Coloured areas denote presence of abnormal (hyperintense) white matter in 3D fluid-attenuated inversion recovery sequences. As can be estimated visually, abnormal white matter was more extensive in patients with coronary microcirculatory dysfunction (above) than in those without coronary microcirculatory dysfunction (below).