G-Rg5 and G-Rk1 bound to Annexin A2. (A) Results of molecular docking shows the interaction between Annexin A2 and G-Rg5. (B) Cellular thermal shift assay presented the thermal stability of Annexin A2 under treatment with G-Rg5 (12 μmol/L) and G-Rk1 (12 μmol/L). (C) Thermal shift in vitro showed the thermal stability of purified Annexin A2 (0.2 μmol/L) under treatment with G-Rg5 and G-Rk1